Improvement of oocyte quality through the SIRT signaling pathway

Kim Cat Tuyen Vo; Yorino Sato; Kazuhiro Kawamura

doi:10.1002/rmb2.12510

Improvement of oocyte quality through the SIRT signaling pathway

Reprod Med Biol. 2023 Feb 23;22(1):e12510. doi: 10.1002/rmb2.12510. eCollection 2023 Jan-Dec.

Authors

Kim Cat Tuyen Vo^{1

2}, Yorino Sato^{1

3}, Kazuhiro Kawamura^{1

3}

Affiliations

¹ Graduate School of Medicine International University of Health and Welfare School of Medicine Narita-shi Japan.
² Department of Obstetrics & Gynaecology University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City Vietnam.
³ Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine Bunkyoku Japan.

Abstract

Background: Oocyte quality is one of the major deciding factors in female fertility competence.

Methods: PubMed database was searched for reviews by using the following keyword "oocyte quality" AND "Sirtuins". The methodological quality of each literature review was assessed using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement.

Main findings: Oxidative stress has been recognized as the mechanism attenuating oocyte quality. Increasing evidence from animal experiments and clinical studies has confirmed the protective roles of the sirtuin family in improving oocyte quality via an antioxidant effect.

Conclusion: The protective roles in the oocyte quality of the sirtuin family have been increasingly recognized.

Keywords: infertility; oocyte; ovarian aging; oxidative stress; sirtuins.

Publication types

Review