A retrospective review of non‑intestinal‑type adenocarcinoma of nasal cavity and paranasal sinus

Jinmei Li; Baofeng Li; Jin Xu; Huimin Wang; Qingzu Gao; Feng Ye; Yuting Xu; Shuhua Wu; Shuqiong Cheng; Yinghao Lu; Jian Guan; Bei Chen

doi:10.3892/ol.2023.13718

A retrospective review of non‑intestinal‑type adenocarcinoma of nasal cavity and paranasal sinus

Oncol Lett. 2023 Feb 14;25(3):132. doi: 10.3892/ol.2023.13718. eCollection 2023 Mar.

Authors

Jinmei Li¹, Baofeng Li², Jin Xu¹, Huimin Wang¹, Qingzu Gao³, Feng Ye¹, Yuting Xu¹, Shuhua Wu¹, Shuqiong Cheng¹, Yinghao Lu¹, Jian Guan¹, Bei Chen¹

Affiliations

¹ Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
² Department of Orthopaedics, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510010, P.R. China.
³ Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Abstract

Non-intestinal adenocarcinoma of nasal cavity and paranasal sinuses (n-ITAC) is a heterogeneous tumor, which has rarely been reported in previous studies. Most high-grade n-ITAC has poor prognosis and there is a lack of classic therapeutic strategy. The present study examined using the PACS system of Nanfang Hospital of Southern Medical University between January 2000 and June 2020. It searched the keyword 'n-ITAC' and selected pathology. A total of 15 consecutive patients were searched. Finally, the present study analyzed a total of 12 n-ITAC patients. The follow-up time was 47 months on average. For low-grade (G1) tumors, 1 and 3-year overall survival (OS) rate were 100 and 85.7% respectively, while for high-grade (G3) tumors, 1 and 3-year OS rates were 80.0 and 20.0% respectively. Pathological grade may be an adverse prognostic factor (P=0.077). The OS of the surgery group was significantly superior to that of the non-surgery group (3-year OS was 63.6 vs. 0%, P=0.0009). Surgery is an indispensable means of treatment. The OS of patients with positive incisal margin was lower compared with that of patients with negative margin (P=0.186), suggesting that complete resection may be one of the prognostic factors. Patients with high risk factors received radiotherapy. The radiation dose was 66-70 Gy/33F for patients with positive margin or non-operation and was 60 Gy/28F for those with negative margin. Most of the patients received prophylactic irradiation of cervical area. Therefore, the prognosis of pathological high-grade n-ITAC is poor. Surgery is the most effective and an indispensable treatment for n-ITAC. For patients with high risk factors, surgery combined with radiotherapy may be a reasonable treatment. With regard to the cover range of radiotherapy, the primary tumor combined with lymph node drainage area is often used in Nanfang Hospital of Southern Medical University and the total dose of radiotherapy can be reduced if the surgical margin is negative.

Keywords: non-intestinal adenocarcinoma of nasal cavity and paranasal sinuses; overall survival; prognosis; radiotherapy; surgery.

Grants and funding

Funding: No funding was received.