Metastasis prevention: How to catch metastatic seeds

Tatiana S Gerashchenko; Anastasia A Schegoleva; Anna A Khozyainova; Evgeny L Choinzonov; Evgeny V Denisov

doi:10.1016/j.bbcan.2023.188867

Metastasis prevention: How to catch metastatic seeds

Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188867. doi: 10.1016/j.bbcan.2023.188867. Epub 2023 Feb 24.

Authors

Tatiana S Gerashchenko¹, Anastasia A Schegoleva¹, Anna A Khozyainova², Evgeny L Choinzonov³, Evgeny V Denisov⁴

Affiliations

¹ Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str. 5, Tomsk 634009, Russia; Laboratory of Single Cell Biology, Research Institute of Molecular and Cellular Medicine, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., Moscow 117198, Russia.
² Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str. 5, Tomsk 634009, Russia.
³ Department of Head and Neck Cancer, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str. 5, Tomsk 634009, Russia.
⁴ Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Kooperativny Str. 5, Tomsk 634009, Russia; Laboratory of Single Cell Biology, Research Institute of Molecular and Cellular Medicine, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., Moscow 117198, Russia. Electronic address: d_evgeniy@oncology.tomsk.ru.

PMID: 36842768
DOI: 10.1016/j.bbcan.2023.188867

Abstract

Despite considerable advances in the evolution of anticancer therapies, metastasis still remains the main cause of cancer mortality. Therefore, current strategies for cancer cure should be redirected towards prevention of metastasis. Targeting metastatic pathways represents a promising therapeutic opportunity aimed at obstructing tumor cell dissemination and metastatic colonization. In this review, we focus on preclinical studies and clinical trials over the last five years that showed high efficacy in suppressing metastasis through targeting lymph node dissemination, tumor cell extravasation, reactive oxygen species, pre-metastatic niche, exosome machinery, and dormancy.

Keywords: Anticancer therapy; Cancer; Dormancy; Exosome; Extravasation; Metastasis prevention; Pre-metastatic niche; Reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Neoplasm Metastasis* / diagnosis
Neoplasms* / pathology