Insights into organoid-based modeling of COVID-19 pathology

Mohadese Hashem Boroojerdi; Tariq Al Jabry; Seyed Mohamad Javad Mirarefin; Halima Albalushi

doi:10.1186/s12985-023-01996-2

Insights into organoid-based modeling of COVID-19 pathology

Virol J. 2023 Feb 25;20(1):37. doi: 10.1186/s12985-023-01996-2.

Authors

Mohadese Hashem Boroojerdi¹, Tariq Al Jabry², Seyed Mohamad Javad Mirarefin³, Halima Albalushi⁴

Affiliations

¹ Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
² Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
³ Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
⁴ Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. halima07@squ.edu.om.

Abstract

Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.

Keywords: COVID-19; Organoid; Regenerative medicine; SARS-CoV-2; Stem cell.

Publication types

Review

MeSH terms

COVID-19 Drug Treatment
COVID-19*
Humans
Organoids
SARS-CoV-2