Pathogenic role of Th17 cells in autoimmune thyroid disease and their underlying mechanisms

Yi Wang; Sijie Fang; Huifang Zhou

doi:10.1016/j.beem.2023.101743

Pathogenic role of Th17 cells in autoimmune thyroid disease and their underlying mechanisms

Best Pract Res Clin Endocrinol Metab. 2023 Mar;37(2):101743. doi: 10.1016/j.beem.2023.101743. Epub 2023 Feb 8.

Authors

Yi Wang¹, Sijie Fang², Huifang Zhou³

Affiliations

¹ Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China; Chinese Consortium for Thyroid Eye Disease (CCTED), China; Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China. Electronic address: wyourmail@163.com.
² Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China; Chinese Consortium for Thyroid Eye Disease (CCTED), China; Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China. Electronic address: fangsijie89@hotmail.com.
³ Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China; Chinese Consortium for Thyroid Eye Disease (CCTED), China. Electronic address: fangzzfang@163.com.

PMID: 36841747
DOI: 10.1016/j.beem.2023.101743

Abstract

Autoimmune thyroid disease, encompassing Graves' disease and Hashimoto's thyroiditis, has a very complex etiology. Pathogenesis of the disease involves both genetic susceptibility and environmental triggers. Traditionally, imbalance of T helper cell 1 and 2 was thought to result in the immune disorders in Graves' disease and Hashimoto's thyroiditis. However, increasing evidence recently revealed the important role of T helper 17 cell and its relative cellular and secretory components in the pathogenesis and progression of autoimmune thyroid disease. This review is aimed to summarize the published studies on the involvement of T helper 17 cell in autoimmune thyroid disease and discuss the underlying regulatory mechanisms, which could possibly serve as the foundation of discovering new therapeutic targets.

Keywords: Graves’ disease; Hashimoto’s thyroiditis; Th17 cell; Th17/Treg imbalance; autoimmune thyroid disease.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Genetic Predisposition to Disease
Graves Disease*
Hashimoto Disease*
Humans
Th17 Cells / pathology