Advances in Self-Assembled Peptides as Drug Carriers

Pharmaceutics. 2023 Feb 1;15(2):482. doi: 10.3390/pharmaceutics15020482.

Abstract

In recent years, self-assembled peptide nanotechnology has attracted a great deal of attention for its ability to form various regular and ordered structures with diverse and practical functions. Self-assembled peptides can exist in different environments and are a kind of medical bio-regenerative material with unique structures. These materials have good biocompatibility and controllability and can form nanoparticles, nanofibers and hydrogels to perform specific morphological functions, which are widely used in biomedical and material science fields. In this paper, the properties of self-assembled peptides, their influencing factors and the nanostructures that they form are reviewed, and the applications of self-assembled peptides as drug carriers are highlighted. Finally, the prospects and challenges for developing self-assembled peptide nanomaterials are briefly discussed.

Keywords: drug carriers; influencing factors; nanostructures; peptides; self-assembly.

Publication types

  • Review

Grants and funding

This work was supported by the University Natural Science Research Project of Anhui Province (KJ2020A0157), Key Laboratory of Xin’an Medicine Open Project Fund (Anhui University of Chinese Medicine) Ministry of Education (No. 2020xayx02) and Drug Regulatory scientific research key project (AHYJ-KJ-202206, Central of Regulatory Science for Medical Products, Anhui Province).