ADP-Ribosylation in Antiviral Innate Immune Response

Qian Du; Ying Miao; Wei He; Hui Zheng

doi:10.3390/pathogens12020303

ADP-Ribosylation in Antiviral Innate Immune Response

Pathogens. 2023 Feb 12;12(2):303. doi: 10.3390/pathogens12020303.

Authors

Qian Du^{1

2}, Ying Miao^{1

2}, Wei He^{1

2}, Hui Zheng^{1

2}

Affiliations

¹ Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
² Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China.

Abstract

Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD⁺) to the target substrate and release the nicotinamide (Nam). Accordingly, it comes in two forms: mono-ADP-ribosylation (MARylation) and poly-ADP-ribosylation (PARylation). ADP-ribosylation plays important roles in many biological processes, such as DNA damage repair, gene regulation, and energy metabolism. Emerging evidence demonstrates that ADP-ribosylation is implicated in host antiviral immune activity. Here, we summarize and discuss ADP-ribosylation modifications that occur on both host and viral proteins and their roles in host antiviral response.

Keywords: ADP-ribosylation; IFN-I; MARylation; PARylation; antiviral response; innate immunity; post-translational modifications; viral infection.

Publication types

Review

Grants and funding

This work is supported by the National Natural Science Foundation of China (32241009, 31970846) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).