Magnolol, a Neolignan-like Drug, Inhibits Porcine Epidemic Diarrhea Virus Replication in Cultured Cells

Xiaoting Wang; Bingqing Chen; Ruisong Yu; Fusheng Si; Chunfang Xie; Zhen Li; Shijuan Dong; Daojing Zhang

doi:10.3390/pathogens12020263

Magnolol, a Neolignan-like Drug, Inhibits Porcine Epidemic Diarrhea Virus Replication in Cultured Cells

Pathogens. 2023 Feb 6;12(2):263. doi: 10.3390/pathogens12020263.

Authors

Xiaoting Wang¹, Bingqing Chen², Ruisong Yu², Fusheng Si², Chunfang Xie², Zhen Li², Shijuan Dong², Daojing Zhang¹

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology (ECUST), Shanghai 200237, China.
² Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Engineering Research Center of Breeding Pig, Institute of Animal Husbandry and Veterinary Science, Shanghai Academy of Agricultural Sciences (SAAS), Shanghai 201106, China.

Abstract

Porcine epidemic diarrhea virus (PEDV) is a destructive pathogen that continues to adversely affect the swine industry worldwide due to a current lack of vaccines and drugs capable of effective disease control. In the present study, the neolignan-like drug, magnolol (MAG), was tested for its ability to inhibit a Vero-cell adapted PEDV strain DR13^att. Our data revealed that MAG exhibited anti-PEDV activity in vitro, with IC₅₀ and CC₅₀ values of 28.21 μM and 57.28 μM, respectively. MAG was an efficient inhibitor of viral replication, and repression of viral proliferation was strongest when the host cells were exposed to MAG and the virus at the same time. Although our data indicate that MAG has the potential to be a useful PEDV control agent, in vivo testing of the drug, using animal hosts, is required.

Keywords: antiviral effect; in vitro; magnolol; porcine epidemic diarrhea virus (PEDV).

Abstract

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