Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia

Manuela Labbozzetta; Paola Poma; Monica Notarbartolo

doi:10.3390/ijms24044140

Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia

Int J Mol Sci. 2023 Feb 18;24(4):4140. doi: 10.3390/ijms24044140.

Authors

Manuela Labbozzetta¹, Paola Poma¹, Monica Notarbartolo¹

Affiliation

¹ Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.

Abstract

Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance to both classic chemotherapy and emerging drugs. Multidrug resistance (MDR) is a complex process determined by multiple mechanisms, and it is often caused by the overexpression of efflux pumps, the most important of which is P-glycoprotein (P-gp). This mini-review aims to examine the advantages of using natural substances as P-gp inhibitors, focusing on four molecules: phytol, curcumin, lupeol, and heptacosane, and their mechanism of action in AML.

Keywords: P-glycoprotein; acute myeloid leukemia; multidrug resistance; natural substances.

Publication types

Review

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1* / antagonists & inhibitors
Curcumin* / therapeutic use
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Humans
Leukemia, Myeloid, Acute* / drug therapy

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Curcumin

Grants and funding

This research received no external funding.