Disease-Specific Quality of Life among Patients with Peripheral Artery Disease in Hungary

Lilla Horváth; Imre Boncz; Zsuzsanna Kívés; Gergely Fehér; Noémi Németh; Fanni Luca Kajos; Katalin Biró; Krisztina Fendrik; Katalin Koltai; Gábor Késmárky; Dóra Endrei

doi:10.3390/ijerph20043558

Disease-Specific Quality of Life among Patients with Peripheral Artery Disease in Hungary

Int J Environ Res Public Health. 2023 Feb 17;20(4):3558. doi: 10.3390/ijerph20043558.

Authors

Lilla Horváth¹, Imre Boncz^{2

3}, Zsuzsanna Kívés², Gergely Fehér⁴, Noémi Németh², Fanni Luca Kajos^{2

3}, Katalin Biró⁵, Krisztina Fendrik⁵, Katalin Koltai⁵, Gábor Késmárky⁵, Dóra Endrei^{2

5}

Affiliations

¹ Centre for Occupational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
² Institute for Health Insurance, Faculty of Health Sciences, University of Pécs, 7621 Pécs, Hungary.
³ National Laboratory on Human Reproduction, University of Pécs, 7624 Pécs, Hungary.
⁴ Department of Primary Health Care, University of Pécs, 7623 Pécs, Hungary.
⁵ 1st Department of Internal Medicine, Medical School, Clinical Center, University of Pécs, 7624 Pécs, Hungary.

Abstract

Peripheral artery disease (PAD) is a progressive atherosclerotic disease significantly impacting functional status and health-related quality of life (HRQoL). This study aimed to investigate HRQoL among PAD patients in Hungary using the validated Hungarian version of the PADQoL questionnaire. Patients with symptomatic PAD were consecutively recruited from the Department of Angiology, Clinical Center, University of Pécs, Hungary. Demographics, risk factors, and comorbidities were registered. Disease severity was measured by Fontaine and WIFI stages. Descriptive statistical analysis, Chi-square test, and non-parametric tests were performed (p < 0.05). Overall, 129 patients (mean age 67.6 ± 11.9 years, men 51.9%) participated in our study. The Hungarian PADQoL demonstrated good internal consistency (α range: 0.745-0.910). Factors on intimate and social relationships gave the best (89.15 ± 20.91; 63.17 ± 26.05) and sexual function (28.64 ± 27.42), and limitations in physical functioning (24.68 ± 11.40) the worst scores. PAD had a significant negative impact on the social relationships of patients aged 21-54 years (51.6 ± 25.4). Fontaine stage IV patients experienced significantly lower HRQoL due to fear and uncertainty (46.3 ± 20.9) and limited physical functioning (33.2 ± 24.8). The Hungarian PADQoL identified central aspects of HRQoL. Advanced PAD was found to impact several areas of HRQoL, primarily physical functioning and psycho-social well-being, drawing attention to the importance of early diagnosis and management.

Keywords: PADQoL; health related quality of life; peripheral artery disease; questionnaire validation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Comorbidity
Humans
Hungary
Male
Middle Aged
Peripheral Arterial Disease* / epidemiology
Quality of Life*
Risk Factors
Surveys and Questionnaires

Grants and funding

The research was financed by the Thematic Excellence Program 2021 Health Sub-program of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-10 project of the University of Pécs. This research was funded by the project RRF-2.3.1-21-2022-00012, National Laboratory on Human Reproduction.