Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient

Aleksandar Kalauzi; Zoran Matić; Mirjana M Platiša; Tijana Bojić

doi:10.3390/bioengineering10020180

Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient

Bioengineering (Basel). 2023 Jan 31;10(2):180. doi: 10.3390/bioengineering10020180.

Authors

Aleksandar Kalauzi¹, Zoran Matić², Mirjana M Platiša³, Tijana Bojić⁴

Affiliations

¹ Department for Life Sciences, Institute for Multidisciplinary Research, University of Belgrade, 11030 Belgrade, Serbia.
² Biomedical Engineering and Technologies, University of Belgrade, 11000 Belgrade, Serbia.
³ Institute of Biophysics, Faculty of Medicine, University of Belgrade, P.O. Box 22, 11129 Belgrade, Serbia.
⁴ Department of Radiation Chemistry and Physics 030, "VINČA" Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, P.O. Box 522, Mike Petrovića Alasa 12-14, 11000 Belgrade, Serbia.

Abstract

Due to the fact that respiratory breath-to-breath and cardiac intervals between two successive R peaks (BBI and RRI, respectively) are not temporally concurrent, in a previous paper, we proposed a method to calculate both the integer and non-integer parts of the pulse respiration quotient (PRQ = BBI/RRI = PRQ_int + b1 + b2), b1 and b2 being parts of the border RRIs for each BBI. In this work, we study the correlations between BBI and PRQ, as well as those between BBI and mean RRI within each BBI (mRRI), on a group of twenty subjects in four conditions: in supine and standing positions, in combination with spontaneous and slow breathing. Results show that the BBI vs. PRQ correlations are positive; whereas the breathing regime had little or no effect on the linear regression slopes, body posture did. Two types of scatter plots were obtained with the BBI vs. mRRI correlations: one showed points aggregated around the concurrent PRQ_int lines, while the other showed randomly distributed points. Five out of six of the proposed aggregation measures confirmed the existence of these two cardio-respiratory coupling regimes. We also used b1 to study the positions of R pulses relative to the respiration onsets and showed that they were more synchronous with sympathetic activation. Overall, this method should be used in different pathological states.

Keywords: cardio-respiratory coupling; cardio-respiratory synchronization; heart rate variability; pulse respiration quotient; slow breathing; sympatho-vagal balance.

Grants and funding

This work was supported by the Ministry for Science, Technological Development, and Innovation of the Republic of Serbia T0302303 and the Project Proof of Concept 5537, Innovation Fund of the Republic of Serbia.