Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor

Chem Commun (Camb). 2023 Mar 28;59(26):3838-3841. doi: 10.1039/d3cc00332a.

Abstract

We demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we achieve by repurposing a Soxhlet apparatus to realize the slow removal and fast re-addition of solvent autonomously.