Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population

Shaoyuan Zhang; Yong Fang; Feng Su; Tian Jiang; Jinjie Yu; Siyun Lin; Lu Lv; Tao Long; Huiwen Pan; Junqing Qi; Qiang Zhou; Weifeng Tang; Guowen Ding; Liming Wang; Lijie Tan; Jun Yin

doi:10.1155/2023/6922909

Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population

J Oncol. 2023 Feb 14:2023:6922909. doi: 10.1155/2023/6922909. eCollection 2023.

Authors

Shaoyuan Zhang^{1

2}, Yong Fang^{1

2}, Feng Su^{1

2}, Tian Jiang^{1

2}, Jinjie Yu^{1

2}, Siyun Lin^{1

2}, Lu Lv³, Tao Long³, Huiwen Pan³, Junqing Qi³, Qiang Zhou⁴, Weifeng Tang⁵, Guowen Ding³, Liming Wang⁶, Lijie Tan^{1

2}, Jun Yin^{1

2}

Affiliations

¹ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
² Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
³ Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Jiangsu 212002, China.
⁴ Department of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Sichuan 610042, China.
⁵ Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Jiangsu 210008, China.
⁶ Department of Respiratory, Shanghai Xuhui Central Hospital, Shanghai 200031, China.

Abstract

Introduction: LAMA1, also known as laminin subunit α1, is a member of the laminin family, which is widely reported to be a key basement membrane molecule that affects various biological activities and is associated with many kinds of diseases. We aimed to investigate the association between LAMA1single-nucleotide polymorphisms and the occurrence and progression of esophageal squamous cell carcinoma in the Chinese population.

Method: 2,186 participants were collected retrospectively between October 2008 and January 2017, including 1,043 ESCC patients and 1,143 noncancer patients. A 2 mL blood sample was obtained intravenously for the LDR for SNP analysis. The 6 SNP loci of LAMA1 were selected and examined. We analyzed the association of several genetic models of 6 LAMA1 SNP loci, sex, age, smoking and drinking status, and the occurrence of esophageal squamous cell carcinoma.

Results: In the rs62081531 G > A locus, genotype GA was a protective factor for ESCC compared with GG (OR: 0.830, P=0.046), especially among the younger and nondrinkers. At rs607230 T > C, genotype TC was linked with a lower risk of ESCC compared with TT. (OR: 0.613, P=0.034). Haplotype Frequencies revealed that A_rs62081531G_rs621993A_rs539713T_rs566655A_rs73938538C_rs607230 (OR: 0.803, P=0.028) and G_rs62081531G_rs621993A_rs539713T_rs566655C_rs73938538C_rs607230 (OR: 0.679, P=0.010) were strongly associated with lower susceptibility of ESCC.

Conclusion: The LAMA1 rs62081531, rs539713, rs566655, and rs607230 polymorphisms were demonstrated to be related to susceptibility to ESCC in the Chinese population. LAMA1 SNPs may have a significant impact on the occurrence of esophageal cancer and may serve as potential diagnostic biomarkers.