Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

Z Wu; S H Korntner; A M Mullen; D I Zeugolis

doi:10.1016/j.bbiosy.2021.100030

Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

Biomater Biosyst. 2021 Nov 22:4:100030. doi: 10.1016/j.bbiosy.2021.100030. eCollection 2021 Dec.

Authors

Z Wu¹, S H Korntner¹, A M Mullen², D I Zeugolis^{1

3}

Affiliations

¹ Regenerative, Modular & Developmental Engineering Laboratory (REMODEL) and Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway (NUI Galway), Galway, Ireland.
² Teagasc Research Centre, Ashtown, Ireland.
³ Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Charles Institute of Dermatology, Conway Institute of Biomolecular & Biomedical Research and School of Mechanical & Materials Engineering, University College Dublin (UCD), Dublin, Ireland.

Abstract

Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering approaches are primarily based on collagen type I devices that are associated with suboptimal functional therapeutic outcomes. Herein, we briefly describe cartilage's development and cellular and extracellular composition and organisation. We also provide an overview of collagen type II biosynthesis and purification protocols from tissues of terrestrial and marine species and recombinant systems. We then advocate the use of collagen type II as a building block in cartilage engineering approaches, based on safety, efficiency and efficacy data that have been derived over the years from numerous in vitro and in vivo studies.

Keywords: Articular cartilage; Chondrocytes; Chondrogenic induction; Collagen type II.

Publication types

Review