The role of (pro)renin receptor and its soluble form in cardiovascular diseases

Boyang Wang; Haipeng Jie; Shuangxi Wang; Bo Dong; Yunzeng Zou

doi:10.3389/fcvm.2023.1086603

The role of (pro)renin receptor and its soluble form in cardiovascular diseases

Front Cardiovasc Med. 2023 Feb 2:10:1086603. doi: 10.3389/fcvm.2023.1086603. eCollection 2023.

Authors

Boyang Wang^{1

2

3}, Haipeng Jie^{1

2}, Shuangxi Wang⁴, Bo Dong^{1

2

3}, Yunzeng Zou⁵

Affiliations

¹ Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
² Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
³ Department of Cardiology, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁴ Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, China.
⁵ Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

Abstract

The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a new member of RAS in 2002. Studies have demonstrated the effects of PRR and its soluble form in local tissue RAS. Moreover, as an important part of vacuolar H⁺-ATPase, it also contributes to normal lysosome function and cell survival. Evidently, PRR participates in the pathogenesis of cardiovascular diseases and may be a potential therapeutic target of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on the physiological state, hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis. We aimed to investigate the possibilities and challenges of PRR and its soluble form as a new therapeutic target in cardiovascular diseases.

Keywords: (pro)renin receptor; cardiovascular disease; fibrosis; hypertension; renin-angiotensin system.

Publication types

Review

Grants and funding

This study was supported by the National Natural Science Foundation of China (Nos. 81870283, 81570729, 82070382, and 81601721) and the Program of Taishan Scholars Programme (No. ts 20190979).