The Role of Mesenchymal Stem Cells and Exosomes in Tumor Development and Targeted Antitumor Therapies

Enguang Yang; Suoshi Jing; Yuhan Wang; Hanzhang Wang; Ronald Rodriguez; Zhiping Wang

doi:10.1155/2023/7059289

The Role of Mesenchymal Stem Cells and Exosomes in Tumor Development and Targeted Antitumor Therapies

Stem Cells Int. 2023 Feb 14:2023:7059289. doi: 10.1155/2023/7059289. eCollection 2023.

Authors

Enguang Yang¹, Suoshi Jing¹, Yuhan Wang¹, Hanzhang Wang², Ronald Rodriguez³, Zhiping Wang¹

Affiliations

¹ Institute of Urology, Lanzhou University Second Hospital; Key Laboratory of Gansu Province for Urological Diseases; Gansu Nephro-Urological Clinical Center, 730030 Lanzhou, China.
² Department of Pathology and Laboratory Medicine, UConn Health, Farmington, CT, USA.
³ Department of Urology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA.

Abstract

Mesenchymal stem cells (MSCs) can be isolated from various tissues in adults and differentiated into cells of the osteoblasts, adipocytes, chondrocytes, and myocytes. Recruitments of MSCs towards tumors have a crucial contribution to tumor development. However, the role of MSCs in the tumor microenvironment is uncertain. In addition, due to its tropism to the tumor and low immunogenic properties, more and more pieces of evidence indicate that MSCs may be an ideal carrier for antitumor biologics such as cytokines, chemotherapeutic agents, and oncolytic viruses. Here, we review the existing knowledge on the anti- and protumorigenic effect of MSCs and their extracellular vesicles and exosomes, the role of MSCs, and their extracellular vesicles and exosomes as antitumor vectors.

Publication types

Review