Cyclotron production of 103Pd using a liquid target

Abstract

Introduction: In this work, we present the first feasibility study on the production of the medically important radionuclide ¹⁰³Pd via the ¹⁰³Rh(p,n)¹⁰³Pd reaction by cyclotron irradiation of a liquid target. Using a liquid target removes the time consuming and complex dissolution process of rhodium post-irradiation due to its chemically inactive nature and thereby will improve the accessibility of this radioisotope.

Methods: Liquid targets made from Rh(NO₃)₃·×H₂O salt dissolved in de-ionized water were irradiated using a 12 MeV beam at the TR13 cyclotron at TRIUMF, Vancouver.

Results: A maximum EOB activity of 1.03 ± 0.05 MBq was achieved with the tested conditions, sufficient for basic radiochemistry studies. An effective separation method using anion exchange chromatography is reported using 1 M HNO₃ as an eluent for rhodium (90.1 ± 2.1 % recovery) and a 1:1 mixture of 0.5 M NH₃ + NH₄Cl palladium eluent (103.8 ± 2.3 % recovery). The solution showed good in-target pressure stability. However, the production efficiency decreased significantly with higher solution concentrations and irradiation lengths which puts into question the scaling potential of this method.

Conclusion: This proof-of-concept study has demonstrated the potential for using liquid targets as complementary production method of ¹⁰³Pd for research purposes. The liquid target route faces several scaling challenges but can nonetheless improve the availability of ¹⁰³Pd and consequently aid in widening its utility for radiopharmaceuticals.

Keywords: (103)Pd; Liquid targets; Radioisotope production; Targeted radionuclide therapy; Targetry.