On-surface synthesis has emerged as a powerful tool to fabricate various functional low-dimensional nanostructures with atomic precision, thus becoming a promising platform for the preparation of next-generation semiconductive, magnetic, and topological nanodevices. With the aid of scanning tunneling microscopy/spectroscopy and noncontact atomic force microscopy, both the chemical structures and physical properties of the obtained products can be well characterized. A major challenge in this field is how to efficiently steer reaction pathways and improve the yield/quality of products. To address this problem, in recent years various kinetic and thermodynamic strategies have been successfully employed to control on-surface reactions. In this Perspective, we discuss these strategies in view of basic reaction steps on surfaces, including molecular adsorption, diffusion, and reaction. We hope this Perspective will help readers to deepen the understanding of the mechanisms of on-surface reactions and rationally design reaction procedures for the fabrication of high-quality functional nanomaterials on surfaces.