The hyperspectral full polarization imaging system (HFPIS) based on spatial modulation and liquid crystal tunable filter (LCTF) can modulate the polarization information of the target into the interferogram by means of interference imaging. It has the advantage of rapid imaging of the hyperspectral full polarization information from the target, and has good real time imaging and practicality. Through the spectroscopic imaging mode of a Savart prism, the corresponding interference optical path and imaging system are designed, including a beam expander, spatial modulator, LCTF, focusing system, and imaging sensor. This system can extract the different information from the target and demodulate it so as to obtain the hyperspectral polarization image. The experiment shows that the HFPIS can reveal the texture, contour, and other details of the target in the fog, and has obvious advantages over the traditional intensity imaging methods.