Mitochondrial membrane biogenesis: A new pathway for lipid transport mediated by PERK/E-Syt1 complex

J Cell Biol. 2023 Mar 6;222(3):e202301132. doi: 10.1083/jcb.202301132. Epub 2023 Feb 23.

Abstract

Despite decades of extensive research, mitochondrial lipid transport is a process far from fully understood. In this issue, Sassano et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202206008) identified a new complex, composed of E-Syt1 and PERK, which mediates lipid transport at ER-mitochondria contact sites and regulates mitochondrial functions in human cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Lipid Metabolism*
  • Mitochondria* / metabolism
  • Mitochondrial Membranes* / metabolism
  • Organelle Biogenesis
  • Synaptotagmin I / metabolism
  • eIF-2 Kinase

Substances

  • Synaptotagmin I
  • SYT1 protein, human
  • EIF2AK3 protein, human
  • eIF-2 Kinase