Aim: To assess the serum levels of HSP70 concentrations in ectopic pregnancy (EP) patients compared with abortus imminens (AI) patients and healthy controls. Materials & methods: Age-matched patients were divided into three groups, with 30 patients in each group: EP, AI and healthy intrauterine pregnancy groups. Blood samples were taken from the antecubital vein and kept for HSP70 analysis. Results: The HSP70 levels were higher in the EP group than in AI patients and healthy controls (p < 0.05). The area under the curve for the serum HSP70 assay reached a value of 0.81 for a cutoff point of 11.12 pg/ml, which identified women with EP. Conclusion: Serum HSP70 levels increased in women with EP compared with healthy controls and women with AI.
Keywords: HSP70; abortus imminens; biomarker; ectopic pregnancy; heat shock protein; pregnancy; pregnancy of unknown location.
A pregnancy outside the uterus is called ectopic pregnancy. While diagnosing these patients, consecutive blood tests and serial vaginal examinations are used. Abortus imminens, which is in the differential diagnosis of ectopic pregnancy, means impending miscarriage or abortion. The aim of this study was to evaluate the relationship between HSP70 serum levels and pregnancies in which the exact location is unknown. Therefore, the study determined that HSP70 increased in ectopic pregnancy patients compared with abortus imminens and healthy patient groups.