Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)

Hiroki Mizumaki; Ken Ishiyama; Jun Aoki; Jinichi Mori; Shohei Mizuno; Noriko Doki; Takahiro Fukuda; Naoyuki Uchida; Masahito Onizuka; Masatsugu Tanaka; Yuta Katayama; Yukiyasu Ozawa; Kazuhiro Ikegame; Satoru Takada; Toshiro Kawakita; Nobuyuki Aotsuka; Yoshiko Atsuta; Masamitsu Yanada

doi:10.1002/jha2.609

Outcomes after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with der(1;7)(q10;p10)

EJHaem. 2022 Nov 6;4(1):251-257. doi: 10.1002/jha2.609. eCollection 2023 Feb.

Authors

Hiroki Mizumaki¹, Ken Ishiyama¹, Jun Aoki², Jinichi Mori³, Shohei Mizuno⁴, Noriko Doki⁵, Takahiro Fukuda², Naoyuki Uchida⁶, Masahito Onizuka⁷, Masatsugu Tanaka⁸, Yuta Katayama⁹, Yukiyasu Ozawa¹⁰, Kazuhiro Ikegame¹¹, Satoru Takada¹², Toshiro Kawakita¹³, Nobuyuki Aotsuka¹⁴, Yoshiko Atsuta^{15

16}, Masamitsu Yanada¹⁷

Affiliations

¹ Department of Hematology Kanazawa University Hospital Kanazawa Japan.
² Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital Tokyo Japan.
³ Department of Hematology Jyoban Hospital of Tokiwa Foundation Fukushima Japan.
⁴ Division of Hematology Department of Internal Medicine Aichi Medical University Nagakute Japan.
⁵ Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan.
⁶ Department of Hematology Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital Tokyo Japan.
⁷ Department of Hematology and Oncology Tokai University School of Medicine Isehara Japan.
⁸ Department of Hematology Kanagawa Cancer Center Yokohama Japan.
⁹ Department of Hematology Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital Hiroshima Japan.
¹⁰ Department of Hematology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital Nagoya Japan.
¹¹ Department of Hematology Hyogo Medical University Hospital Hyogo Japan.
¹² Leukemia Research Center Saiseikai Maebashi Hospital Maebashi Japan.
¹³ Department of Hematology National Hospital Organization Kumamoto Medical Center Kumamoto Japan.
¹⁴ Division of Hematology-Oncology Japanese Red Cross Society Narita Hospital Narita Japan.
¹⁵ Japanese Data Center for Hematopoietic Cell Transplantation Nagoya Japan.
¹⁶ Department of Registry Science for Transplant and Cellular Therapy Aichi Medical University School of Medicine Nagakute Japan.
¹⁷ Department of Hematology and Cell Therapy Aichi Cancer Center Nagoya Japan.

Abstract

The prognosis of acute myeloid leukemia (AML) patients with der(1;7)(q10;p10) who underwent allogeneic hematopoietic stem cell transplantation (allo-SCT) is unclear due to its rarity. We retrospectively analyzed 151 AML patients with der(1;7)(q10;p10) and compared the findings with those of 853 AML patients with monosomy 7 or chromosome 7q deletion (-7/del(7q)) using Japanese nationwide registry data. The der(1;7)(q10;p10) group showed significantly better transplant outcomes than the -7/del(7q) group. In the multivariate analysis of the der(1;7)(q10;p10) group, additional chromosomal abnormalities and a poor performance status significantly influenced the survival. In conclusion, allo-SCT is a feasible treatment option for AML patients with der(1;7)(q10;p10).

Keywords: AML; additional chromosomal abnormalities; allogeneic hematopoietic stem cell transplantation; der(1;7)(q10;p10).