Background: COVID-19 is a new pandemic that has infected millions of people worldwide and caused a high morbidity and mortality rate. COVID-19 may have a harmful effect on organs, especially the kidneys. Aims: The main aim of our research is to study the association between the severity of COVID-19 disease and biochemical parameters related to kidney function and to investigate certain risk factors of COVID-19-associated kidney disease.
Methods: A total of 174 individuals, 121 COVID-19 positive and 53 COVID-19 negative, were enrolled in this study. The relation between COVID-19 infection, severity, kidney function test, and hematological indicators were examined.
Results: The most prominent symptoms among COVID-19 were fever (95% ) and fatigue (92%). Regarding biochemical parameters, median creatinine, MPV, and CRP were significantly higher in COVID-19 patients, whereas median eGFR, Na+, WBC, MCH, MCHC, and eosinophil percentages were significantly lower in this group. Severely infected patients were observed to have higher urea, creatinine, neutrophils, and NLR. However, median sodium, eGFR, hemoglobin, hematocrit, RBC, lymphocytes, and platelet count were significantly lower in the severe group. Urine examination of the severe group showed a significantly lower specific gravity, while urine pH, protein, and glucose were significantly higher.
Conclusions: Our analysis indicates that COVID-19 infection affects kidney function, mainly creatinine level, urea, eGFR, Na+ and urine protein. Additionally, comorbidities such as older age (>65), hypertension, taking medications, and CRP (>33.55 mg/L) are considered risk factors that are more likely to contribute to kidney impairment in COVID-19 positive patients.
Uvod: KOVID-19 je nova pandemija koja je zarazila milione ljudi širom sveta i izazvala visoku stopu morbiditeta i mortaliteta. KOVID-19 može imati štetan uticaj na organe, posebno na bubrege. Ciljevi: Glavni cilj našeg istraživanja je da se prouci povezanost između težine bolesti KOVID-19 i biohemijskih parametara vezanih za funkciju bubrega i da se ispitaju određeni faktori rizika od bolesti bubrega povezanih sa KOVID-19.
Metode: Ova studija je ukljucila ukupno 174 osobe, od kojih je 121 bila pozitivna na KOVID-19, a 53 sa negativnim nalazom. Ispitivana je veza između ozbiljnosti infekcije, testa funkcije bubrega i hematoloških pokazatelja.
Rezultati: Najistaknutiji simptomi među pacijentima obolelim od KOVID-19 su bili povišena temperatura (95%) i umor (92%). Sto se tice biohemijskih parametara, srednji kreatinin, MPV i CRP su bili znacajno viši kod pacijenata sa KOVID-19, dok su medijani eGFR, Na+, VBC, MCH, MCHC i procenti eozinofila bili znacajno niži u ovoj grupi. Primećeno je da pacijenti sa teškom infekcijom imaju povišenu ureu, kreatinin, neutrofile i NLR. Međutim, medijani natrijuma, eGFR, hemoglobina, hematokrita, eritrocita, limfocita i broja trombocita su bili znacajno niži u grupi pacijenata sa težim oblikom oboljenja. Ispitivanje urina kod grupe sa težim oblikom bolesti je ukazalo na znacajno manju specificnu težinu, dok su pH urina, proteini i glukoza bili znacajno viši.
Zaključak: Naša analiza ukazuje da KOVID-19 utiče na funkciju bubrega, uglavnom na nivo kreatinina, ureju, eGFR, Na+ i proteine u urinu. Pored toga, komorbiditeti kao što su starija životna dob (>65), hipertenzija, uzimanje lekova i CRP (>33,55 mg/L) se smatraju faktorima rizika koji će verovatno doprineti oštećenju bubrega kod pacijenata pozitivnih na KOVID-19.
Keywords: CBC; COVID-19; CRP creatinine; kidney; urine analysis.
2023 Yosra Mohammed Yaghmour, Shraim Ala'a Said, Abbas Manal Ahmad, published by CEON/CEES.