Plant-derived Ren's oligopeptide has antiviral effects on influenza virus and SARS-CoV-2

Chengzhi Yu; Yayu Huang; Xin Ren; Leqiang Sun

doi:10.3389/fvets.2022.1090372

Plant-derived Ren's oligopeptide has antiviral effects on influenza virus and SARS-CoV-2

Front Vet Sci. 2023 Feb 2:9:1090372. doi: 10.3389/fvets.2022.1090372. eCollection 2022.

Authors

Chengzhi Yu¹, Yayu Huang¹, Xin Ren², Leqiang Sun^{1

3}

Affiliations

¹ College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
² Wuhan Shiji Maide Biotechnology Company, Wuhan, China.
³ State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.

Abstract

Influenza virus and SARS-CoV-2 virus are two important viruses that cause respiratory tract diseases. The high-frequency mutation of the two types of viruses leads to failure of the durable immune protection of vaccines, meanwhile it also poses continuous challenges to the development of antiviral drugs. Traditional Chinese medicine contains large number of biologically active compounds, and some of them contain broad-spectrum antiviral ingredients. In this study, we extracted antiviral active ingredients from medicinal and edible plants by biotransformation and enzymatic hydrolysis as a drug, and we named this drug Ren's oligopeptide. Further, we analyzed the antiviral activity of this drug and found that Ren's oligopeptide could inhibit the replication of influenza virus and SARS-CoV-2 virus with high anti-virus activities. In vitro experiments showed that the antiviral activity of the Ren's oligopeptide mainly targets the replication process after virus enters the cell. Therefore, Ren's oligopeptide is a promising drug against influenza and COVID-19.

Keywords: Ren's oligopeptide; SARS-CoV-2; antiviral drugs; influenza virus; virus replication.