Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study

Jingyu Zhou; Zhiwen Ye; Peng Wei; Feng Yi; Min Ouyang; Shilang Xiong; Yayun Liu; Jintang Li; Min Liu; Hanrui Xi; Qianyi Peng; Long Xiong

doi:10.3389/fpubh.2023.1096519

Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study

Front Public Health. 2023 Feb 1:11:1096519. doi: 10.3389/fpubh.2023.1096519. eCollection 2023.

Authors

Jingyu Zhou¹, Zhiwen Ye^{2

3

4}, Peng Wei¹, Feng Yi¹, Min Ouyang¹, Shilang Xiong⁵, Yayun Liu⁶, Jintang Li⁶, Min Liu¹, Hanrui Xi¹, Qianyi Peng^{2

3

4}, Long Xiong¹

Affiliations

¹ Department of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
² Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.
³ Hunan Provincial Clinical Research Center for Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China.
⁴ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Hospital, Central South University, Changsha, China.
⁵ Department of Orthopaedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
⁶ Department of Orthopaedics, People's Hospital Affiliated with Nanchang University, Nanchang, Jiangxi, China.

Abstract

Purpose: Basal metabolic rate may play a key role in the pathogenesis and progression of osteoporosis. We performed Mendelian random analysis to evaluate the causal relationship between basal metabolic rate and osteoporosis.

Methods: Instrumental variables for the basal metabolic rate were selected. We used the inverse variance weighting approach as the main Mendelian random analysis method to estimate causal effects based on the summary-level data for osteoporosis from genome-wide association studies.

Results: A potential causal association was observed between basal metabolic rate and risks of osteoporosis (odds ratio = 0.9923, 95% confidence interval: 0.9898-0.9949; P = 4.005^{e - 09}). The secondary MR also revealed that BMR was causally associated with osteoporosis (odds ratio = 0.9939, 95% confidence interval: 0.9911-0.9966; P = 1.038^{e - 05}). The accuracy and robustness of the findings were confirmed using sensitivity tests.

Conclusion: Basal metabolic rate may play a causal role in the development of osteoporosis, although the underlying mechanisms require further investigation.

Keywords: Mendelian randomization; aging; basal metabolic rate; genome-wide association study; osteoporosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Basal Metabolism
Genome-Wide Association Study*
Humans
Mendelian Randomization Analysis
Osteoporosis*
Polymorphism, Single Nucleotide

Grants and funding

This work was supported by the National Natural Science Foundation of China (82160528, 82160354, 81974285, 81901264, and 82172145), the Natural Science Foundation of Jiangxi Province (2021BAB206059 and 20224ACB206012), and the Natural Science Foundation of Hunan Province (2020JJ5959 and 2020JJ5918).