Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus

O I Koifman; V E Maizlish; M O Koifman; N Sh Lebedeva; E S Yurina; Yu A Gubarev; E L Gur'ev

doi:10.1007/s11172-023-3728-y

Complexation ability of tetrasulfosubstituted cobalt(II) phthalocyanine toward ORF3a protein of SARS-CoV-2 virus

Russ Chem Bull. 2023;72(1):233-238. doi: 10.1007/s11172-023-3728-y. Epub 2023 Feb 14.

Authors

O I Koifman^{1

2}, V E Maizlish², M O Koifman^{1

2}, N Sh Lebedeva¹, E S Yurina¹, Yu A Gubarev¹, E L Gur'ev³

Affiliations

¹ G. A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, 1 ul. Akademicheskaya, 153045 Ivanovo, Russian Federation.
² Ivanovo State University of Chemistry and Technology, 7 Sheremetevskii prosp., 153000 Ivanovo, Russian Federation.
³ Lobachesky State University of Nizhny Novgorod, 4 Ashkhabadskaya ul., 603105 Nizhny Novgorod, Russian Federation.

Abstract

Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine affords a stable complex in which metallophthalocyanine exists in the monomeric form. The complex formation induces slight changes in the secondary structure of the protein by increasing the fraction of disordered fragments of the polypeptide chain. The photoirradiation of the complex of ORF3a protein of SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine leads to the photooxidation of amino acid residues of the protein.

Keywords: complex formation; photooxidation; phthalocyanine; protein; virus SARS-CoV-2.