The immunomodulation role of Th17 and Treg in renal transplantation

Front Immunol. 2023 Feb 1:14:1113560. doi: 10.3389/fimmu.2023.1113560. eCollection 2023.

Abstract

Kidney transplantation (KT) is an ultimate treatment of end-stage chronic kidney disease, which can meet a lot of complications induced by immune system. With under-controlled immunosuppression, the patient will obtain a good prognosis. Otherwise, allograft disfunction will cause severe organ failure and even immune collapse. Acute or chronic allograft dysfunction after KT is related to Th17, Treg, and Th17/Treg to a certain extent. Elevated Th17 levels may lead to acute rejection or chronic allograft dysfunction. Treg mainly plays a protective role on allografts by regulating immune response. The imbalance of the two may further aggravate the balance of immune response and damage the allograft. Controlling Th17 level, improving Treg function and level, and adjusting Th17/Treg ratio may have positive effects on longer allograft survival and better prognosis of receptors.

Keywords: T cell; Th17; Th17/Treg; Treg; renal transplantation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Immunity
  • Immunomodulation
  • Kidney Transplantation*
  • T-Lymphocytes, Regulatory
  • Th17 Cells

Grants and funding

This work was supported by the Clinical Research Plan of SHDC (grant number SHDC2020CR4067) and by the Shanghai Science and Technology Commission (grant numbers 20S31905300 and 20Y11900900).