Myeloidderived suppressor cells: Escorts at the maternal-fetal interface

Bo Pang; Cong Hu; Huimin Li; Xinyu Nie; Keqi Wang; Chen Zhou; Huanfa Yi

doi:10.3389/fimmu.2023.1080391

Myeloidderived suppressor cells: Escorts at the maternal-fetal interface

Front Immunol. 2023 Feb 2:14:1080391. doi: 10.3389/fimmu.2023.1080391. eCollection 2023.

Authors

Bo Pang^{1

2}, Cong Hu^{1

3}, Huimin Li^{1

4}, Xinyu Nie^{1

3}, Keqi Wang^{1

2}, Chen Zhou⁵, Huanfa Yi¹

Affiliations

¹ Central Laboratory, First Hospital of Jilin University, Changchun, Jilin, China.
² Cardiology Department, First Hospital of Jilin University, Changchun, Jilin, China.
³ Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jilin, China.
⁴ Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China.
⁵ General Department, First Hospital of Jilin University, Changchun, Jilin, China.

Abstract

Myeloid-derived suppressor cells (MDSCs) are a novel heterogenous group of immunosuppressive cells derived from myeloid progenitors. Their role is well known in tumors and autoimmune diseases. In recent years, the role and function of MDSCs during reproduction have attracted increasing attention. Improving the understanding of their strong association with recurrent implantation failure, pathological pregnancy, and neonatal health has become a focus area in research. In this review, we focus on the interaction between MDSCs and other cell types (immune and non-immune cells) from embryo implantation to postpartum. Furthermore, we discuss the molecular mechanisms that could facilitate the therapeutic targeting of MDSCs. Therefore, this review intends to encourage further research in the field of maternal-fetal interface immunity in order to identify probable pathways driving the accumulation of MDSCs and to effectively target their ability to promote embryo implantation, reduce pathological pregnancy, and increase neonatal health.

Keywords: embryo implantation; maternal–fetal immune tolerance; myeloid-derived suppressor cells (MDSCs); newborn; pregnancy complications.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases* / metabolism
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Embryo Implantation
Female
Humans
Infant, Newborn
Myeloid-Derived Suppressor Cells*
Pregnancy

Grants and funding

This study was supported by the Science and Technology Department of Jilin Province (YDZJ202201ZYTS085, 20220204020YY, and YDZJ202201ZYTS027) and the National Natural Science Foundation of China (82201847).