Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)

Zhizhong Hu; Yitong Liu; Meiqi Liu; Yang Zhang; Chengkun Wang

doi:10.3892/ol.2023.13693

Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)

Oncol Lett. 2023 Feb 2;25(3):107. doi: 10.3892/ol.2023.13693. eCollection 2023 Mar.

Authors

Zhizhong Hu¹, Yitong Liu¹, Meiqi Liu¹, Yang Zhang¹, Chengkun Wang¹

Affiliation

¹ Cancer Research Institute, Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.

Abstract

Long non-coding RNAs (lncRNAs) are a class of RNAs that are >200 nucleotides in length that do not have the ability to be translated into protein but are associated with numerous diseases, including cancer. The involvement of lncRNAs in the signalling of certain signalling pathways can promote tumour progression; these pathways include the transforming growth factor (TGF)-β signalling pathway, which is related to tumour development. The expression of lncRNAs in various tumour tissues is specific, and their interaction with the TGF-β signalling pathway indicates that they may serve as new tumour markers and therapeutic targets. The present review summarized the role of TGF-β pathway-associated lncRNAs in regulating tumorigenesis in different types of cancer and their effects on the TGF-β signalling pathway.

Keywords: TGF-β signalling pathway; cancer; lncRNA.

Publication types

Review

Grants and funding

The present study was supported by the Youth Program of National Natural Science Foundation of China (grant no. 81500169), the Hunan Provincial Groundbreaking Platform Open Fund of University of South China (grant no. 19K080) and the Student Research Learning and Innovative Experimental Project of the University of South China (grant nos. 20155760439 and X2019141).