Relationship between NUDT21 mediated alternative polyadenylation process and tumor

Shan Xiao; Huan Gu; Li Deng; Xiongtao Yang; Dan Qiao; Xudong Zhang; Tian Zhang; Tao Yu

doi:10.3389/fonc.2023.1052012

Relationship between NUDT21 mediated alternative polyadenylation process and tumor

Front Oncol. 2023 Feb 2:13:1052012. doi: 10.3389/fonc.2023.1052012. eCollection 2023.

Authors

Shan Xiao¹, Huan Gu², Li Deng¹, Xiongtao Yang², Dan Qiao², Xudong Zhang³, Tian Zhang², Tao Yu^{1

2}

Affiliations

¹ Department of Oncology, Affiliated Hospital of Southwest Medical University of China, Luzhou, China.
² Department of Head and Neck Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
³ Department of Anesthesia, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Abstract

Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3' end of RNA polymerase II transcripts from over 60% of human genes. APA and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. As a key molecular mechanism, Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA 3' UTRs. Nudix Hydrolase 21 (NUDT21) is a crucial mediator involved in alternative polyadenylation (APA). Different studies have reported a dual role of NUDT21 in cancer (both oncogenic and tumor suppressor). The present review focuses on the functions of APA, miRNA and their interaction and roles in development of different types of tumors.NUDT21 mediated 3' UTR-APA changes can be used to generate specific signatures that can be used as potential biomarkers in development and disease. Due to the emerging role of NUDT21 as a regulator of the aforementioned RNA processing events, modulation of NUDT21 levels may be a novel viable therapeutic approach.

Keywords: NUDT21; alternative polyadenylation; microRNA; therapy; tumor.

Publication types

Review

Grants and funding

Foundatios: [Science and technology support plan of Sichuan Science and Technology Department] (2014SZ0005); [Application Foundation Project of Science and Technology Department of Sichuan Province] (2019YJ0572).