Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp

Xinyang Li; Jinzhong Xu; Pinmei Wang; Wanjing Ding

doi:10.1080/21501203.2022.2069173

Novel indole diketopiperazine stereoisomers from a marine-derived fungus Aspergillus sp

Mycology. 2022 Apr 29;14(1):1-10. doi: 10.1080/21501203.2022.2069173. eCollection 2023.

Authors

Xinyang Li¹, Jinzhong Xu¹, Pinmei Wang¹, Wanjing Ding¹

Affiliation

¹ Institute of Marine Biology and Pharmacology, Ocean College, Zhejiang University, Zhoushan, China.

Abstract

Four dimeric diketopiperazine stereoisomers (1-4) including two new ones (1-2) had been isolated from the culture broth of one marine-derived fungus Aspergillus sp. Z3, which was found in the gut of a marine isopod Ligia exotica. The planner structures and absolute configurations of the new compounds were determined by combination of NMR, HRESIMS, electronic circular dichroism calculation, Marfey's method as well as single-crystal X-ray diffraction. Their cytotoxicity against the prostate cancer PC3 cell line was assayed by the MTT method.

Keywords: Indole diketopiperazine; dimer; gut fungus; stereoisomers.

Grants and funding

This work was financially supported by the Zhoushan City–Zhejiang University Joint Specific Project [No. 2020C81004].