Analytical approaches for determination of COVID-19 candidate drugs in human biological matrices

Rabee Mahdavi; Zahra Talebpour

doi:10.1016/j.trac.2023.116964

Analytical approaches for determination of COVID-19 candidate drugs in human biological matrices

Trends Analyt Chem. 2023 Mar:160:116964. doi: 10.1016/j.trac.2023.116964. Epub 2023 Feb 13.

Authors

Rabee Mahdavi¹, Zahra Talebpour^{1

2}

Affiliations

¹ Department of Analytical Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran, Iran.
² Analytical and Bioanalytical Research Centre, Alzahra University, Vanak, Tehran, Iran.

Abstract

Since the outbreak of the COVID-19 pandemic, the use of antiviral and other available drugs has been considered to combat or reduce the clinical symptoms of patients. In this regard, it would be necessary to choose sensitive and selective analytical techniques for pharmacokinetic and pharmacodynamic studies, monitoring of drug concentration in biological fluids, and determination of the most appropriate dose to achieve the desired effect on the disease. In the present study, the analytical techniques based on spectroscopy and chromatography with different detectors for diagnosis and determination of candidate drugs in the treatment of COVID-19 in human biological fluids are reviewed during the period 2015-2022. Moreover, various sample preparation and extraction techniques, are being used for this purpose, such as protein precipitation (PP), solid-phase extraction (SPE), liquid-liquid extraction (LLE), and QuEChERS (quick, easy, cheap, effective, rugged, and safe) are investigated.

Keywords: Chromatography; Drug analysis; SARS-COV-2; Sample preparation; Solid-phase microextraction; Spectroscopy.

Publication types

Review