A new chromone derivative from an endophytic Aspergillus sp. GXNU-B1

Aijuan Feng; Wenxiu Zhang; Lixia Wang; Junqiang Zhou; Jinwei Chen; Xiaoyun Xu; Xishan Huang; Jiguo Huang

doi:10.1080/14786419.2023.2181805

A new chromone derivative from an endophytic Aspergillus sp. GXNU-B1

Nat Prod Res. 2023 Feb 23:1-6. doi: 10.1080/14786419.2023.2181805. Online ahead of print.

Authors

Aijuan Feng¹, Wenxiu Zhang², Lixia Wang¹, Junqiang Zhou¹, Jinwei Chen¹, Xiaoyun Xu¹, Xishan Huang², Jiguo Huang¹

Affiliations

¹ School of Chemical Engineering and Technology, Guangdong Industry Polytechnic, Guangdong Engineering Technical Research Center for Green Household Chemicals, Guangzhou, China.
² State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, P. R. China.

PMID: 36815551
DOI: 10.1080/14786419.2023.2181805

Abstract

A new chromone derivative, aspergione A (1), along with seven known metabolites, was isolated from a mangrove endophytic fungus, Aspergillus sp. GXNU-B1, which was collected from mangrove Acanthus ilicifolius L. Their structures and the absolute configuration of 1 were elucidated based on the analysis of HR-ESI-MS, NMR, and ECD calculation. Compounds 1-8 were evaluated for their anti-inflammatory effects on the production of nitricoxide (NO). Compounds 1 and 8 have potent inhibitory effects against NO production in activated macrophages with IC₅₀ values of 38.26 and 44.30 μM, respectively.

Keywords: Aspergillus sp.; anti-inflammatory effect; aspergione A; mangrove endophytic fungus.