Function of sildenafil on diseases other than urogenital system: An umbrella review

Zeyu Chen; Yin Huang; Dehong Cao; Shi Qiu; Bo Chen; Jin Li; Yige Bao; Qiang Wei; Ping Han; Liangren Liu

doi:10.3389/fphar.2023.1033492

Function of sildenafil on diseases other than urogenital system: An umbrella review

Front Pharmacol. 2023 Feb 6:14:1033492. doi: 10.3389/fphar.2023.1033492. eCollection 2023.

Authors

Zeyu Chen^{1

2}, Yin Huang^{1

2}, Dehong Cao¹, Shi Qiu¹, Bo Chen^{1

2}, Jin Li^{1

2}, Yige Bao¹, Qiang Wei¹, Ping Han¹, Liangren Liu¹

Affiliations

¹ Department of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
² West China School of Clinical Medicine, Sichuan University, Chengdu, China.

Abstract

Background: To investigate the function of sildenafil on diseases other than urogenital system, an umbrella review was conducted. Methods: Meta-analysis and systematic reviews on this topic were comprehensively evaluated in this umbrella review. Quality of evidence was evaluated through AMSTAR and the Grading of Recommendations, Assessment, Development and Evaluation system to generate a reliable and valid conclusion. Results: 77 out of 1164 meta-analysis were enrolled. 33 significant outcomes and 41 non-significant outcomes were extracted from all eligible articles. We found sildenafil did significant help in reducing arterial systolic pressure, mean pulmonary arterial pressure, pulmonary arterial pressure, systolic pulmonary arterial pressure in patients with pulmonary and cardiovascular diseases. Besides, sildenafil also improved exercise capacity or performance in patients with pulmonary and cardiovascular diseases. Other than these patients, this drug contributed great help in pregnant women with fetal growth restriction and preeclampsia by increasing the weight of newborns and lowering uterine and umbilical pulsatility indices. Additionally, it was reported that utilization of sildenafil has brought increased risk of melanoma. Conclusion: We can conclude from our study that sildenafil played an important role in many fields, especially in vascular protection. This finding provides a strong evidence for further expansion of sildenafil utilization in other diseases.

Keywords: phosphodiesterase-5 inhibitor; sildenafil; therapeutic function; umbrella review; vascular dysfunction.

Grants and funding

This study was funded by the National Natural Science Foundation of China (grant number 82000721) and Program from Department of Science and Technology of Sichuan Province (grant number 2020YJ0054).