Five new limonoids isolated from Walsura robusta

Li Hou; Cui-Xuan Mei; Chun-Mao Yuan; Gui-Hua Tang; Duo-Zhi Chen; Qing Zhao; Hong-Ping He; Ming-Ming Cao; Xiao-Jiang Hao

doi:10.1007/s13659-023-00371-6

Five new limonoids isolated from Walsura robusta

Nat Prod Bioprospect. 2023 Feb 23;13(1):7. doi: 10.1007/s13659-023-00371-6.

Authors

Li Hou^#^{1

2

3}, Cui-Xuan Mei^#^{1

4}, Chun-Mao Yuan^{1

5}, Gui-Hua Tang¹, Duo-Zhi Chen¹, Qing Zhao², Hong-Ping He^{6

7}, Ming-Ming Cao⁸, Xiao-Jiang Hao^{9

10

11

12}

Affiliations

¹ State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
² School of Ethnic Medicine, and School of Chinese Materia Medical, Yunnan University of Chinese Medicine, Kunming, 650500, China.
³ Bureau of Commerce and Market Supervision of Management Committee of Hunan Xiangjiang New Area, Changsha, 410205, China.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁵ The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China.
⁶ State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. hehongping@yahoo.com.
⁷ School of Ethnic Medicine, and School of Chinese Materia Medical, Yunnan University of Chinese Medicine, Kunming, 650500, China. hehongping@yahoo.com.
⁸ State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. caomingming@mail.kib.ac.cn.
⁹ State Key Laboratory of Photochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China. haoxj@mail.kib.ac.cn.
¹⁰ The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, China. haoxj@mail.kib.ac.cn.
¹¹ Research Unit of Chemical Biology of Natural Anti-Virus Products, Chinese Academy of Medical Sciences, Beijing, 100730, China. haoxj@mail.kib.ac.cn.
¹² Yunnan Characteristic Plant Extraction Laboratory, Kunming, 650106, China. haoxj@mail.kib.ac.cn.

^# Contributed equally.

Abstract

Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1-4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1-6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.

Keywords: Cytotoxicity; Limonoids; Tetranortriterpenoids; Walsura robusta.

Abstract

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