Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL

Teresa Sadras; Fatimah B Jalud; Hansen J Kosasih; Christopher R Horne; Lauren M Brown; Sam El-Kamand; Charles E de Bock; Lachlan McAloney; Ashley P Ng; Nadia M Davidson; Louise E A Ludlow; Alicia Oshlack; Mark J Cowley; Seong L Khaw; James M Murphy; Paul G Ekert

doi:10.1038/s41375-023-01843-x

Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL

Leukemia. 2023 Apr;37(4):905-909. doi: 10.1038/s41375-023-01843-x. Epub 2023 Feb 21.

Authors

Teresa Sadras^#^{1

2}, Fatimah B Jalud^#¹, Hansen J Kosasih³, Christopher R Horne^{4

5}, Lauren M Brown^{6

7}, Sam El-Kamand⁶, Charles E de Bock^{6

7}, Lachlan McAloney^{1

8}, Ashley P Ng^{1

4

5}, Nadia M Davidson^{4

5

9}, Louise E A Ludlow^{3

8}, Alicia Oshlack^{1

2

10}, Mark J Cowley^{6

7}, Seong L Khaw^{3

8

11}, James M Murphy^{4

5}, Paul G Ekert^{12

13

14

15

16}

Affiliations

¹ Peter MacCallum Cancer Centre, Parkville, VIC, Australia.
² The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
³ Murdoch Children's Research Institute, Parkville, VIC, Australia.
⁴ Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
⁵ Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
⁶ Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, NSW, Australia.
⁷ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.
⁸ Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
⁹ School of Biosciences, University of Melbourne, Parkville, VIC, Australia.
¹⁰ School of Mathematics and Statistics, University of Melbourne, Parkville, VIC, Australia.
¹¹ Children's Cancer Centre, Royal Children's Hopsital, Parkville, VIC, Parkville, Australia.
¹² Peter MacCallum Cancer Centre, Parkville, VIC, Australia. paul.ekert@petermac.org.
¹³ The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia. paul.ekert@petermac.org.
¹⁴ Murdoch Children's Research Institute, Parkville, VIC, Australia. paul.ekert@petermac.org.
¹⁵ Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, NSW, Australia. paul.ekert@petermac.org.
¹⁶ School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia. paul.ekert@petermac.org.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Oncogene Proteins, Fusion* / genetics
Phosphotransferases
Receptor, Platelet-Derived Growth Factor beta* / genetics

Substances

Oncogene Proteins, Fusion
PDGFRB protein, human
Phosphotransferases
Receptor, Platelet-Derived Growth Factor beta