Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition?

Abstract

Purpose: To assess whether the high metabolic region of fluorine-18-fluorode-oxyglucose (¹⁸F-FDG) in the primary lesion is the crux for recurrence in patients with nasopharyngeal carcinoma (NPC), to assess the feasibility and rationale for use of biological target volume (BTV) based on ¹⁸F-FDG positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT).

Methods: The retrospective study included 33 patients with NPC who underwent ¹⁸F-FDG-PET/CT at the time of initial diagnosis as well as the time of diagnosis of local recurrence. Paired ¹⁸F-FDG-PET/CT images for primary and recurrent lesion were matched by deformation coregistration method to determine the cross-failure rate between two lesions.

Results: The median volume of the V_pri (primary tumor volume using the SUV thresholds of 2.5), the V_high (the volume of high FDG uptake using the SUV50%max isocontour), and the V_recur (the recurrent tumor volume using the SUV thresholds of 2.5) were 22.85, 5.57, and 9.98 cm³, respectively. The cross-failure rate of V_recur∩high showed that 82.82% (27/33) of local recurrent lesions had < 50% overlap volume with the region of high FDG uptake. The cross-failure rate of V_recur∩pri showed that 96.97% (32/33) of local recurrent lesions had > 20% overlap volume with the primary tumor lesions and the median cross rate was up to 71.74%.

Conclusion: ¹⁸F-FDG-PET/CT may be a powerful tool for automatic target volume delineation, but it may not be the optimal imaging modality for dose escalation radiotherapy based on applicable isocontour. The combination of other functional imaging could delineate the BTV more accurately.

Keywords: 18F-FDG-PET/CT; Biological target volume; Local recurrence; Nasopharyngeal carcinoma; Standardized uptake value.