Vaccine-Preventable Diseases in Older Adults

Maha Al-Jabri; Christian Rosero; Elie A Saade

doi:10.1016/j.idc.2022.11.005

Vaccine-Preventable Diseases in Older Adults

Infect Dis Clin North Am. 2023 Mar;37(1):103-121. doi: 10.1016/j.idc.2022.11.005.

Authors

Maha Al-Jabri¹, Christian Rosero¹, Elie A Saade²

Affiliations

¹ Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue - Mailstop Fol. 5083, Cleveland, OH 44106, USA; Case Western Reserve University, Cleveland, OH, USA.
² Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue - Mailstop Fol. 5083, Cleveland, OH 44106, USA. Electronic address: elie.saade@uhhospitals.org.

PMID: 36805008
DOI: 10.1016/j.idc.2022.11.005

Abstract

Older adults are at an increased risk of vaccine-preventable diseases partly because of physiologic changes in the immune and other body systems related to age and/or accumulating comorbidities that increase the vulnerability to infections and decrease the response to vaccines. Strategies to improve the response to vaccines include using a higher antigenic dose (such as in the high-dose inactivated influenza vaccines) as well as adding adjuvants (such as MF59 in the adjuvanted inactivated influenza vaccine).

Keywords: Herpes zoster; Immunization schedule; Influenza; Older adults; Streptococcus pneumoniae.

Publication types

Review

MeSH terms

Adjuvants, Immunologic / adverse effects
Aged
Humans
Influenza Vaccines* / adverse effects
Influenza, Human* / epidemiology
Influenza, Human* / prevention & control
Polysorbates / adverse effects
Squalene / adverse effects
Vaccine-Preventable Diseases*
Vaccines, Inactivated / adverse effects

Substances

Adjuvants, Immunologic
Influenza Vaccines
Polysorbates
Squalene
Vaccines, Inactivated