Single-chain polymer nanoparticles in biomedical applications

Naomi M Hamelmann; Jos M J Paulusse

doi:10.1016/j.jconrel.2023.02.019

Single-chain polymer nanoparticles in biomedical applications

J Control Release. 2023 Apr:356:26-42. doi: 10.1016/j.jconrel.2023.02.019. Epub 2023 Mar 1.

Authors

Naomi M Hamelmann¹, Jos M J Paulusse²

Affiliations

¹ Department of Molecules and Materials, MESA+ Institute for Nanotechnology and TechMed Institute for Health and Biomedical Technologies, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, the Netherlands.
² Department of Molecules and Materials, MESA+ Institute for Nanotechnology and TechMed Institute for Health and Biomedical Technologies, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, the Netherlands. Electronic address: j.m.j.Paulusse@utwente.nl.

PMID: 36804328
DOI: 10.1016/j.jconrel.2023.02.019

Abstract

Single-chain polymer nanoparticles (SCNPs) are a well-defined and uniquely sized class of polymer nanoparticles. The advances in polymer science over the past decades have enabled the development of a variety of intramolecular crosslinking systems, leading to particles in the 5-20 nm size regime. Which is aligned with the size regime of proteins and therefore making SCNPs an interesting class of NPs for biomedical applications. The high modularity of SCNP design and the ease of their functionalization have led to growing research interest. In this review, we describe different crosslinking systems, as well as the preparation of functional SCNPs and the variety of biomedical applications that have been explored.

Keywords: Antimicrobial; Biomedical applications; Controlled drug delivery; Single chain polymer nanoparticles; Targeted imaging.

Publication types

Review

MeSH terms

Biomedical Technology*
Nanoparticles*
Polymers*
Proteins

Substances

Polymers
Proteins