Advanced delivery systems for peptide antibiotics

Adv Drug Deliv Rev. 2023 May:196:114733. doi: 10.1016/j.addr.2023.114733. Epub 2023 Feb 17.

Abstract

Antimicrobial peptides (AMPs) hold promise as alternatives to traditional antibiotics for preventing and treating multidrug-resistant infections. Although they have potent antimicrobial efficacy, AMPs are mainly limited by their susceptibility to proteases and potential off-site cytotoxicity. Designing the right delivery system for peptides can help to overcome such limitations, thus improving the pharmacokinetic and pharmacodynamic profiles of these drugs. The versatility of peptides and their genetically encodable structure make them suitable for both conventional and nucleoside-based formulations. In this review, we describe the main drug delivery procedures developed so far for peptide antibiotics: lipid nanoparticles, polymeric nanoparticles, hydrogels, functionalized surfaces, and DNA- and RNA-based delivery systems.

Keywords: Antibiotic resistance; Antimicrobial peptides; Cell-based delivery systems; Drug-delivery; Infectious diseases; mRNA-lipid nanoparticle-based therapy.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents* / pharmacology
  • Drug Delivery Systems
  • Humans
  • Peptides / chemistry

Substances

  • Anti-Infective Agents
  • Anti-Bacterial Agents
  • Peptides