Induced epigenetic changes memorized across generations in mice

Saifeng Cheng; Yoav Mayshar; Yonatan Stelzer

doi:10.1016/j.cell.2023.01.023

Induced epigenetic changes memorized across generations in mice

Cell. 2023 Feb 16;186(4):683-685. doi: 10.1016/j.cell.2023.01.023.

Authors

Saifeng Cheng¹, Yoav Mayshar¹, Yonatan Stelzer²

Affiliations

¹ Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.
² Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel. Electronic address: yonatan.stelzer@weizmann.ac.il.

PMID: 36803599
DOI: 10.1016/j.cell.2023.01.023

Abstract

Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.

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MeSH terms

Animals
CpG Islands / genetics
DNA Methylation*
Epigenesis, Genetic*
Inheritance Patterns
Mammals / genetics
Mice