Ultra-precise weak measurement-based interfacial biosensors

Lizhong Zhang; Qiang Huang; Xiaonan Zhang; Zhen Zeng; Hailong Zhang; Tian Guan; Yang Xu; Chongqi Zhou; Lingqin Meng; Gengyu Liang; Zhangyan Li; Bei Wang; Le Liu; Cuixia Guo; Yonghong He

doi:10.1016/j.talanta.2022.124217

Ultra-precise weak measurement-based interfacial biosensors

Talanta. 2023 May 15:257:124217. doi: 10.1016/j.talanta.2022.124217. Epub 2022 Dec 22.

Authors

Lizhong Zhang¹, Qiang Huang², Xiaonan Zhang³, Zhen Zeng¹, Hailong Zhang⁴, Tian Guan³, Yang Xu¹, Chongqi Zhou⁵, Lingqin Meng¹, Gengyu Liang¹, Zhangyan Li⁵, Bei Wang¹, Le Liu⁶, Cuixia Guo⁷, Yonghong He⁸

Affiliations

¹ Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
² Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Shenzhen Shengqiang Technology Co., Ltd, China; Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
³ Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; School of Medicine, Tsinghua University, Beijing, 100084, China.
⁴ Key Laboratory of Photonic Control Technology (Tsinghua University), Ministry of Education, Beijing, 100084, China; Department of Precision Instrument, Tsinghua University, Beijing, 100084, China.
⁵ Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Department of Physics, Tsinghua University, Beijing, 100084, China.
⁶ Institute of Materials Research, Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
⁷ School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, 350108, China. Electronic address: guocx@fzu.edu.cn.
⁸ Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. Electronic address: heyh@sz.tsinghua.edu.cn.

PMID: 36801563
DOI: 10.1016/j.talanta.2022.124217

Abstract

In this study, an interfacial biosensing scheme with ultra-precision is proposed. The scheme uses weak measurement techniques to ensure ultra-high sensitivity of the sensing system while improving the stability of the system through self-referencing and pixel point averaging, thus achieving ultra-high detection accuracy of biological samples. In specific experiments, we have used the biosensor in this study to perform specific binding reaction experiments for protein A and Mouse IgG with a detection line of 2.71 ng/mL for IgG. In addition, the sensor is non-coated, simple in structure, easy to operate, and low in cost of use.

Keywords: Biosensors; Refractive index sensing; Self-referencing; Ultra-precision; Weak measurements.

MeSH terms

Animals
Biosensing Techniques* / methods
Immunoglobulin G
Mice

Substances

Immunoglobulin G