In the spotlight: How the brainstem modulates information flow

Abstract

Objective: The blink reflex (BR) to supraorbital nerve (SON) stimulation is reduced by either a low-intensity prepulse stimulus to digital nerves (prepulse inhibition, PPI) or a conditioning SON stimulus (SON_-1) of the same intensity as the test (SON_-2) stimulus (paired-pulse paradigm). We studied how PPI affects BR excitability recovery (BRER) to paired SON stimulation.

Methods: Electrical prepulses were applied to the index finger 100 ms before SON_-1, which was followed by SON_-2 at interstimulus intervals (ISI) of 100, 300, or 500 ms.

Results: BRs to SON_-1 showed PPI proportional to prepulse intensity, but this did not affect BRER at any ISI. PPI was observed on the BR to SON_-2 only when additional prepulses were applied 100 ms before SON_-2, regardless of the size of BRs to SON_-1.

Conclusions: In BR paired-pulse paradigms, the size of the response to SON_-2 is not determined by the size of the response to SON_-1. PPI does not leave any trace of inhibitory activity after it is enacted.

Significance: Our data demonstrate that BR response size to SON_-2 depends on SON_-1 stimulus intensity and not SON_-1 response size, an observation that calls for further physiological studies and cautions against unanimous clinical applicability of BRER curves.

Keywords: Blink reflex excitability recovery; Conditioning stimulation; Paired-pulse stimulation; Prepulse inhibition; Trigeminal blink reflex.