Increased 18 F-Fluoroestradiol Uptake of Radiation Pneumonitis in a Patient With Metastatic Breast Cancer

Bo Pan; Zhixin Hao; Yidong Zhou; Qiang Sun; Li Huo

doi:10.1097/RLU.0000000000004609

Increased 18 F-Fluoroestradiol Uptake of Radiation Pneumonitis in a Patient With Metastatic Breast Cancer

Clin Nucl Med. 2023 May 1;48(5):437-438. doi: 10.1097/RLU.0000000000004609. Epub 2023 Feb 17.

Authors

Bo Pan¹, Zhixin Hao², Yidong Zhou¹, Qiang Sun¹, Li Huo²

Affiliations

¹ From the Department of Breast Surgery, Peking Union Medical College Hospital.
² Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

PMID: 36800243
DOI: 10.1097/RLU.0000000000004609

Abstract

A 42-year-old woman diagnosed with de-novo stage IV breast cancer underwent 18 F-fluoroestradiol (FES) PET/CT to evaluate the estrogen receptor status of metastatic lesions. The largest pulmonary nodule showed obvious FES uptake, consistent with pulmonary metastases from breast cancer. Interestingly, the images revealed a striking accumulation of FES in ground-glass attenuation in the left lobe of lung, suggestive of radiation pneumonitis.

Publication types

Case Reports

MeSH terms

Adult
Breast Neoplasms* / pathology
Breast Neoplasms* / radiotherapy
Estradiol
Female
Humans
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography / methods
Radiation Pneumonitis* / diagnostic imaging
Receptors, Estrogen

Substances

Estradiol
Receptors, Estrogen