Pharmacokinetics of Novel Oral Cyclic Peptide

Abstract

Protein and peptide drugs have been considered to be valuable for treating disease for many years, capturing more and more of the attention of researchers. Previously, we found a short peptide from the porcine intestine named COX_52-69, which could simultaneously lower blood glucose and insulin response after intraperitoneal injection. And thus, it showed a potential to counter type II diabetes without leading to insulin resistance, mainly caused by high insulin levels in the blood. However, this molecule is not stable in the digestive system and cannot be used via oral administration. Here we employed the circularization technique to modify the peptide and tested its pharmacokinetics.

Keywords: Peptide; cir-COX_52-69; digestive; insulin; oral; pharmacokinetics.