Seroreversion to Chlamydia trachomatis Pgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia

Christine Tedijanto; Solomon Aragie; Sarah Gwyn; Dionna M Wittberg; Taye Zeru; Zerihun Tadesse; Ambahun Chernet; Isabel J B Thompson; Scott D Nash; Thomas M Lietman; Diana L Martin; Jeremy D Keenan; Benjamin F Arnold

doi:10.1101/2023.02.04.23285360

Seroreversion to Chlamydia trachomatis Pgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia

medRxiv [Preprint]. 2023 Dec 21:2023.02.04.23285360. doi: 10.1101/2023.02.04.23285360.

Authors

Christine Tedijanto¹, Solomon Aragie², Sarah Gwyn³, Dionna M Wittberg¹, Taye Zeru⁴, Zerihun Tadesse², Ambahun Chernet², Isabel J B Thompson¹, Scott D Nash⁵, Thomas M Lietman^{1

6

7}, Diana L Martin³, Jeremy D Keenan^{1

6}, Benjamin F Arnold^{1

6}

Affiliations

¹ Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA, USA.
² The Carter Center Ethiopia, Addis Ababa, Ethiopia.
³ Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.
⁴ Amhara Public Health Institute, Bahir Dar, Ethiopia.
⁵ The Carter Center, Atlanta, GA, USA.
⁶ Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
⁷ Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

Abstract

Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a three-year longitudinal cohort in a high transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 (95% CI: 1.6, 3.5) per 100 person-years.

Keywords: Chlamydia trachomatis; Ethiopia; IgG; antibody; seroepidemiology; trachoma.

Publication types

Preprint

Abstract

Publication types

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