Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

Miki Tanaka; Tomoaki Okuda; Kouichi Itoh; Nami Ishihara; Ami Oguro; Yoshiaki Fujii-Kuriyama; Yu Nabetani; Megumi Yamamoto; Christoph F A Vogel; Yasuhiro Ishihara

doi:10.1186/s12989-023-00517-x

Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation

Part Fibre Toxicol. 2023 Feb 16;20(1):6. doi: 10.1186/s12989-023-00517-x.

Authors

Miki Tanaka^{1

2}, Tomoaki Okuda³, Kouichi Itoh², Nami Ishihara¹, Ami Oguro¹, Yoshiaki Fujii-Kuriyama⁴, Yu Nabetani⁵, Megumi Yamamoto⁶, Christoph F A Vogel^{7

8}, Yasuhiro Ishihara^{9

10}

Affiliations

¹ Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1, Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8521, Japan.
² Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa, 769-2101, Japan.
³ Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, 223-8522, Japan.
⁴ Medical Research Institute, Molecular Epidemiology, Tokyo Medical and Dental University, Bunkyo, Tokyo, 113-8510, Japan.
⁵ Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Miyazaki, 889-2192, Japan.
⁶ Department of Environment and Public Health, National Institute for Minamata Disease, Minamata, Kumamoto, 867-0008, Japan.
⁷ Department of Environmental Toxicology, University of California, Davis, Davis, CA, 95616, USA.
⁸ Center for Health and the Environment, University of California, Davis, Davis, CA, 95616, USA.
⁹ Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1, Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8521, Japan. ishiyasu@hiroshima-u.ac.jp.
¹⁰ Center for Health and the Environment, University of California, Davis, Davis, CA, 95616, USA. ishiyasu@hiroshima-u.ac.jp.

Abstract

Background: A recent epidemiological study showed that air pollution is closely involved in the prognosis of ischemic stroke. We and others have reported that microglial activation in ischemic stroke plays an important role in neuronal damage. In this study, we investigated the effects of urban aerosol exposure on neuroinflammation and the prognosis of ischemic stroke using a mouse photothrombotic model.

Results: When mice were intranasally exposed to CRM28, urban aerosols collected in Beijing, China, for 7 days, microglial activation was observed in the olfactory bulb and cerebral cortex. Mice exposed to CRM28 showed increased microglial activity and exacerbation of movement disorder after ischemic stroke induction. Administration of core particles stripped of attached chemicals from CRM28 by washing showed less microglial activation and suppression of movement disorder compared with CRM28-treated groups. CRM28 exposure did not affect the prognosis of ischemic stroke in null mice for aryl hydrocarbon receptor, a polycyclic aromatic hydrocarbon (PAH) receptor. Exposure to PM2.5 collected at Yokohama, Japan also exacerbated movement disorder after ischemic stroke.

Conclusion: Particle matter in the air is involved in neuroinflammation and aggravation of the prognosis of ischemic stroke; furthermore, PAHs in the particle matter could be responsible for the prognosis exacerbation.

Keywords: Edema; Inflammation; Ischemic stroke; Particle matter; Polycyclic aromatic hydrocarbons.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air Pollutants* / analysis
Air Pollutants* / toxicity
Animals
China
Environmental Monitoring
Ischemic Stroke*
Mice
Mice, Knockout
Movement Disorders*
Neuroinflammatory Diseases
Particulate Matter / analysis
Particulate Matter / toxicity
Polycyclic Aromatic Hydrocarbons* / analysis

Substances

Particulate Matter
Polycyclic Aromatic Hydrocarbons
Air Pollutants

Abstract

Publication types

MeSH terms

Substances

Grants and funding