Sustainable and practical formation of carbon-carbon and carbon-heteroatom bonds employing organo-alkali metal reagents

Lu-Qiong Huo; Xin-Hao Wang; Zhenguo Zhang; Zhenhua Jia; Xiao-Shui Peng; Henry N C Wong

doi:10.1039/d2sc05475b

Sustainable and practical formation of carbon-carbon and carbon-heteroatom bonds employing organo-alkali metal reagents

Chem Sci. 2022 Dec 21;14(6):1342-1362. doi: 10.1039/d2sc05475b. eCollection 2023 Feb 8.

Authors

Lu-Qiong Huo¹, Xin-Hao Wang¹, Zhenguo Zhang², Zhenhua Jia², Xiao-Shui Peng^{1

3}, Henry N C Wong^{1

3}

Affiliations

¹ School of Science and Engineering, Shenzhen Key Laboratory of Innovative Drug Synthesis, The Chinese University of Hong Kong (Shenzhen) Longgang District Shenzhen China xspeng@cuhk.edu.cn hncwong@cuhk.edu.hk.
² Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University Nanjing 211816 China iaszhjia@njtech.edu.cn.
³ Department of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong Shatin, New Territories Hong Kong SAR China.

Abstract

Metal-catalysed cross-coupling reactions are amongst the most widely used methods to directly construct new bonds. In this connection, sustainable and practical protocols, especially transition metal-catalysed cross-coupling reactions, have become the focus in many aspects of synthetic chemistry due to their high efficiency and atom economy. This review summarises recent advances from 2012 to 2022 in the formation of carbon-carbon bonds and carbon-heteroatom bonds by employing organo-alkali metal reagents.

Publication types

Review