Implantation of XEN gel stent in a patient with ocular cicatricial pemphigoid

Yujia Zhou; Andrew M Philip; Max N Chikovsky; John Nolan; Stephen D Anesi

doi:10.1016/j.ajoc.2023.101801

Implantation of XEN gel stent in a patient with ocular cicatricial pemphigoid

Am J Ophthalmol Case Rep. 2023 Jan 18:29:101801. doi: 10.1016/j.ajoc.2023.101801. eCollection 2023 Mar.

Authors

Yujia Zhou^{1

2}, Andrew M Philip^{1

2}, Max N Chikovsky^{1

2}, John Nolan³, Stephen D Anesi^{1

2}

Affiliations

¹ The Ocular Immunology and Uveitis Foundation, Waltham, MA, USA.
² Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA.
³ Department of Ophthalmology, Boston Medical Center, Boston, MA, USA.

Abstract

Purpose: Herein, we report a case of XEN gel stent implantation in a patient with ocular cicatricial pemphigoid that successfully reduced glaucoma topical medication at one year.

Observations: A 76-year-old male patient presented with severe ocular cicatricial pemphigoid and advanced glaucoma who required several topical medications to control intraocular pressure. Despite successful reduction of ocular inflammation with immunomodulatory therapy, his topical medication regimen prevented total remission of ocular inflammation. One year after XEN gel stent implantation, his intraocular pressures were controlled without any topical medication, and he had no ocular inflammation off any immunomodulatory therapy.

Conclusions and importance: The XEN gel stent represents a useful intervention for glaucoma treatment even in the setting of severe ocular surface disease and can improve outcomes for concurrent inflammatory and glaucomatous pathology.

Keywords: Glaucoma; Minimally invasive glaucoma surgery; Ocular cicatrizing pemphigoid; Uveitis; XEN gel Implant.

Publication types

Case Reports