Immune regulation based on sex differences in ischemic stroke pathology

Pingping Niu; Liqin Li; Yonggang Zhang; Zhongzhou Su; Binghao Wang; He Liu; Shehong Zhang; Sheng Qiu; Yuntao Li

doi:10.3389/fimmu.2023.1087815

Immune regulation based on sex differences in ischemic stroke pathology

Front Immunol. 2023 Jan 30:14:1087815. doi: 10.3389/fimmu.2023.1087815. eCollection 2023.

Authors

Pingping Niu^{1

2}, Liqin Li^{1

2}, Yonggang Zhang^{1

2}, Zhongzhou Su^{1

2}, Binghao Wang^{1

2}, He Liu², Shehong Zhang², Sheng Qiu^{1

2}, Yuntao Li^{1

2}

Affiliations

¹ Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou, China.
² Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuro Modulation, Huzhou, China.

Abstract

Ischemic stroke is one of the world's leading causes of death and disability. It has been established that gender differences in stroke outcomes prevail, and the immune response after stroke is an important factor affecting patient outcomes. However, gender disparities lead to different immune metabolic tendencies closely related to immune regulation after stroke. The present review provides a comprehensive overview of the role and mechanism of immune regulation based on sex differences in ischemic stroke pathology.

Keywords: cytokines; immune cell; immune regulation; ischemic stroke pathology; sex differences.

Publication types

Review

MeSH terms

Brain Ischemia*
Female
Humans
Ischemic Stroke*
Male
Sex Characteristics
Sex Factors
Stroke*